The City Centre is the destination for most transit users, so it's not much of a stretch to say all roads, buses and trains lead here. Waterfront Station is the main hub Cordova, at the foot of Granville St, with the Skytrain, Seabus and many bus routes terminating there. A large number of buses also pickup outside Burrard Station corner of Burrard & Dunsmuir Sts.
Driving into and around downtown isn't usually a problem outside of rush hour, but it can be a nuisance particularly parking, so your best bet is to leave your car outside of the city centre and use SkyTrain from the east or south or SeaBus from the North Shore. If you drive, Georgia Street is the main street through the CBD. It continues on through Stanley Park and the West End and across the Lions Gate Bridge to the North Shore. Access from the south is by bridge over False Creek the Burrard, Granville and Cambie bridges. All of them will lead downtown so just take the one closest to you.
Parking downtown is as you would expect for a city centre: expensive and, at times, hard to find. Expect to pay between $12-25/day for parking in a parkade. On-street parking meters are in effect from 9AM-10PM, 7 days a week. Many of the streets become no parking zones during rush hour.
